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Invitrogen
E-selectin Monoclonal Antibody (P2H3), PE
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FIGURE: 1 / 1
E-selectin Antibody (A16340) in Flow
Human Umbilical Vein Endothelial Cells (HUVEC) were activated with Human TNF alpha Recombinant Protein and stained with Mouse IgG1 kappa Isotype Control PE (open histogram) or Anti-Human CD62E (E-Selectin) PE (filled histogram, A16340). Total viable cells were used for analysis.
Product Details
A16340
Product Specifications
Host/Isotype
Mouse
/ IgG1
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
P2H3
Immunogen
human CD62E
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
10 mg/mL
Storage conditions
4°C
Shipping conditions
Wet ice
RRID
Target Information
Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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