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Invitrogen
CD4 Monoclonal Antibody (RPA-T4), PerCP-Cyanine5.5
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Product Details
A26012
Product Specifications
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
RPA-T4
Immunogen
Human CD4
Conjugate
Excitation/Emission Max
489/679 nm
View spectra
Form
Liquid
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
RRID
Product Specific Information
PerCP-Cy5.5 is a tandem conjugate that combines the peridinin-chlorophyll proteins (PerCP) complexes found in nature with the Cy5.5 cyanine dye, thus permiting simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
This antibody is compatible with the anti-human CD4 antibody OKT4 clone, as it recognizes a different epitope, and thus does not block binding of the OKT4 clone to CD4.
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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