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Bethyl Laboratories
Phospho-SMC3 (Ser383) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-SMC3 (Ser383) Antibody (A300-061A) in IP
Immunoprecipitation of human Phospho SMC3 (Ser383). Samples: Nuclear extracts (50 µg) from HeLa cells that were irradiated with 10 Gy of ionizing radiation or mock irradiated. Antibodies: Rabbit anti-SMC3 pSer383 (Product # A300-061A) was used at 4 µg/mg lysate to IP phospho SMC3 (Ser383). Rabbit anti-SMC3 (Product # A300-060A) was used at 4 µg/mg lysate for IP and at 0.5 µg/mL for WB. Detection: Chemilumin... View More
Product Details
A300-061A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes 3 around serine 383.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, X. laevis, Bovine and Orangutan
Target Information
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bamacan; Basement membrane-associated chondroitin proteoglycan; Chondroitin sulfate proteoglycan 6; chondroitin sulfate proteoglycan 6 (bamacan); Chromosome-associated polypeptide; hCAP; SMC family; SMC protein 3; Structural maintenance of chromosomes protein 3; unnamed protein product
Gene Aliases: BAM; BMH; CDLS3; CSPG6; HCAP; SMC3; SMC3L1
UniProt ID: (Human) Q9UQE7
Entrez Gene ID: (Human) 9126
nucleotide binding
core promoter proximal region sequence-specific DNA binding
chromatin binding
double-stranded DNA binding
microtubule motor activity
protein binding
ATP binding
ATPase activity
mediator complex binding
protein heterodimerization activity
beta-tubulin binding
dynein complex binding
mitotic cell cycle
regulation of DNA replication
DNA repair
cellular response to DNA damage stimulus
sister chromatid cohesion
mitotic sister chromatid cohesion
stem cell population maintenance
establishment of mitotic sister chromatid cohesion
establishment of meiotic sister chromatid cohesion
chromosome organization
cell division
meiotic cell cycle
mitotic spindle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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