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Bethyl Laboratories
BLM Polyclonal Antibody
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FIGURE: 1 / 2
BLM Antibody (A300-120A) in WB
Detection of human BLM by western blot. Samples: Whole cell lysate (50 µg) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified goat anti-BLM antibody (Product # A300-120A) (lot A300-120A-2) used for WB at 0.04 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A300-120A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 100 and 150 of human Bloom Syndrome.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bloom syndrome protein; Bloom syndrome RecQ like helicase; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; DNA helicase, RecQ-like type 2; MGC126616; MGC131618; MGC131620; RecQ protein-like 3; RecQ-like DNA helicase BLM; RecQ2; unnamed protein product
Gene Aliases: BLM; BS; MGRISCE1; RECQ2; RECQL2; RECQL3
UniProt ID: (Human) P54132
Entrez Gene ID: (Human) 641
nucleotide binding
four-way junction DNA binding
Y-form DNA binding
bubble DNA binding
p53 binding
nucleic acid binding
DNA binding
DNA helicase activity
single-stranded DNA binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
zinc ion binding
four-way junction helicase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
isomerase activity
ATPase activity
identical protein binding
protein homodimerization activity
3'-5' DNA helicase activity
metal ion binding
G-quadruplex DNA binding
forked DNA-dependent helicase activity
telomeric D-loop binding
telomeric G-quadruplex DNA binding
8-hydroxy-2'-deoxyguanosine DNA binding
DNA/DNA annealing activity
regulation of cyclin-dependent protein serine/threonine kinase activity
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA replication
DNA repair
DNA recombination
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to X-ray
replication fork processing
telomere maintenance via semi-conservative replication
DNA geometric change
positive regulation of transcription, DNA-templated
negative regulation of DNA recombination
protein oligomerization
protein homooligomerization
negative regulation of cell division
telomeric D-loop disassembly
resolution of recombination intermediates
cellular response to ionizing radiation
cellular response to hydroxyurea
cellular response to camptothecin
t-circle formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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