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Bethyl Laboratories
TBLR1 Polyclonal Antibody
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Product Details
A300-408A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 100 and 150 of Human TBL1-related Protein 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; TBL1X receptor 1; transducin beta like 1 X-linked receptor 1; Transducin beta-like 1X-related protein 1; unnamed protein product
Gene Aliases: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; IRA1; MRD41; TBL1XR1; TBLR1
UniProt ID: (Human) Q9BZK7, (Mouse) Q8BHJ5
Entrez Gene ID: (Human) 79718, (Mouse) 81004
negative regulation of transcription from RNA polymerase II promoter
blastocyst hatching
response to dietary excess
chromatin organization
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
lipid catabolic process
multicellular organism growth
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
white fat cell differentiation
adipose tissue development
fat pad development
regulation of triglyceride metabolic process
positive regulation of canonical Wnt signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone deacetylation
regulation of cAMP metabolic process
canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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