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Bethyl Laboratories

Chk2 Polyclonal Antibody

View all (79) CHK2 antibodies

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Chk2 Polyclonal Antibody

Product Details

A300-620A-T

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 500 and the C-terminus (residue 543) of human Checkpoint Kinase 2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cds1; Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; CHEK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; Chk2-del2-12; Chk2-del2-3; Chk2-del4; Chk2-del7; Chk2-del9; Chk2-del9-12; Chk2-insX; Chk2-insZ; Chk2-iso1; Chk2-iso2; Chk2-sub3; contains FHA domain; del9; EC 2.7.11.1; HuCds 1; Hucds1; kinase Chk2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; RP11-436C9.1; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2; unnamed protein product

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Gene Aliases: CDS1; CHEK2; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53; TPDS4

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UniProt ID: (Human) O96017

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Entrez Gene ID: (Human) 11200

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein kinase binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity metal ion binding protein serine kinase activity
Process(es)
autophagosome assembly DNA damage checkpoint G2/M transition of mitotic cell cycle DNA repair double-strand break repair regulation of transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus response to oxidative stress intrinsic apoptotic signaling pathway in response to DNA damage response to gamma radiation protein catabolic process DNA damage response, signal transduction by p53 class mediator intra-S DNA damage checkpoint cellular response to stress regulation of protein catabolic process response to starvation signal transduction in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator mitotic DNA damage checkpoint positive regulation of transcription, DNA-templated protein autophosphorylation protein stabilization cell division thymocyte apoptotic process protein K63-linked ubiquitination cellular response to xenobiotic stimulus cellular response to gamma radiation mitotic spindle assembly replicative senescence regulation of signal transduction by p53 class mediator response to glycoside cellular response to bisphenol A negative regulation of DNA damage checkpoint positive regulation of anoikis regulation of autophagosome assembly positive regulation of autophagosome assembly
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