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Bethyl Laboratories
PRMT6 Polyclonal Antibody
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FIGURE: 1 / 1
PRMT6 Antibody (A300-928A) in IP
Detection of human PRMT6 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PRMT6 antibody (Product # A300-928A) used for IP at 3 µg/mg lysate. For blotting immunoprecipitated PRMT6, rabbit anti-PRMT6 antibody A300-929A was used at 1 µg/mL,. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A300-928A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 and 50 of Human Protein Arginine Methyltransferase 6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; PRMT-6; PRMT6; type I; Protein arginine N-methyltransferase 6; unnamed protein product
Gene Aliases: HRMT1L6; PRMT6
UniProt ID: (Human) Q96LA8
Entrez Gene ID: (Human) 55170
chromatin binding
protein binding
methyltransferase activity
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
transferase activity
protein-arginine omega-N monomethyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
histone binding
histone methyltransferase activity (H4-R3 specific)
histone methyltransferase activity (H3-R2 specific)
histone methyltransferase activity (H2A-R3 specific)
histone H3 methyltransferase activity
negative regulation of transcription from RNA polymerase II promoter
DNA repair
base-excision repair
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
regulation of mitochondrion organization
methylation
cellular response to stress
regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
cellular senescence
regulation of signal transduction by p53 class mediator
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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