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Bethyl Laboratories
SSH1 Polyclonal Antibody
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FIGURE: 1 / 1
SSH1 Antibody (A301-307A) in WB
Detection of human SSH1 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-SSH1 antibody (Product # A301-307A) used for WB at 0.04 µg/mL (A) and 1 µg/mL (B) and used for IP at 3 µg/mg lysate. SSH1 was also immunoprecipitated by rabbit anti-SSH1 antibodies A301-308A and A301-309A, which recognize downstream epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 1... View More
Product Details
A301-307A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 675 and 725 of Human slingshot homolog 1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSSH-1L; Protein phosphatase Slingshot homolog 1; slingshot homolog 1; SSH-1L; SSH-like protein 1; unnamed protein product
Gene Aliases: KIAA1298; SSH1; SSH1L
UniProt ID: (Human) Q8WYL5
Entrez Gene ID: (Human) 54434
cell morphogenesis
protein dephosphorylation
actin cytoskeleton organization
negative regulation of actin filament polymerization
positive regulation of synaptic plasticity
regulation of protein metabolic process
cellular response to ATP
excitatory chemical synaptic transmission
positive regulation of AMPA glutamate receptor clustering
positive regulation of vascular associated smooth muscle cell migration
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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