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Bethyl Laboratories
Caf1p150 Polyclonal Antibody
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Product Details
A301-481A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 100 and 150 of human chromatin assembly factor 1, subunit A (p150).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
CAF1 p150 is part of the chromatin assembly factor 1 (CAF-1) complex, a key player in DNA repair and replication processes. CAF-1, composed of p150 (CHAF1A), p60 (CHAF1B), and p48 subunits, functions primarily in the deposition of newly synthesized histones H3 and H4 onto nascent DNA strands, ensuring chromatin is properly assembled during DNA replication and after repair. The p150 subunit is the largest of the CAF-1 complex and is critical for binding DNA and recruiting CAF-1 to replication sites, facilitating histone deposition in a process vital for maintaining genome stability and epigenetic inheritance. Beyond just chromatin formation, CAF1 p150 is involved in influencing gene silencing and the maintenance of heterochromatin, impacting gene regulation notably during development and in response to DNA damage. Its role has implications in oncogenesis, where dysregulation of CAF1 p150 can lead to altered chromatin structures and contribute to tumorigenesis, marking it as an important target in cancer research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; Chromatin assembly factor 1 subunit A; chromatin assembly factor I (150 kDa); Chromatin assembly factor I p150 subunit; CTB-50L17.7; hp150; MGC71229
Gene Aliases: CAF; CAF-1; CAF1; CAF1B; CAF1P150; CHAF1A; P150
UniProt ID: (Human) Q13111
Entrez Gene ID: (Human) 10036
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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