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Bethyl Laboratories
MOV10 Polyclonal Antibody
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FIGURE: 1 / 1
MOV10 Antibody (A301-571A) in WB
Detection of human and mouse MOV10 by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-MOV10 antibody (Product # A301-571A) (lot A301-571A-2) used for WB at 0.1 µg/mL (A) and 1 µg/mL (B) and used for IP at 6 µg/mg lysate. MOV10 was also immunoprecipitated by a previous lot (lot A301-571A-1) of this antibody. Detection: Chemiluminescence with exposure ti... View More
Product Details
A301-571A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 953 and 1003 of human Moloney leukemia virus 10, homolog.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Bovine
Target Information
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Armitage homolog; functional spliceosome-associated protein 113; Helicase MOV-10; Moloney leukemia virus 10 protein; Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10, homolog; Putative helicase MOV-10; unnamed protein product
Gene Aliases: C77703; fSAP113; Gb110; KIAA1631; Mov-10; MOV10
UniProt ID: (Human) Q9HCE1, (Mouse) P23249
Entrez Gene ID: (Human) 4343, (Mouse) 17454
negative regulation of transposition, RNA-mediated
gene silencing by RNA
posttranscriptional gene silencing by RNA
gene silencing by miRNA
mRNA cleavage involved in gene silencing by miRNA
defense response to virus
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
transposable element silencing by mRNA destabilization
regulation of neuron projection arborization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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