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Bethyl Laboratories
GTPBP4 Polyclonal Antibody
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FIGURE: 1 / 1
GTPBP4 Antibody (A303-132A-T) in WB
Detection of human GTPBP4 by western blot. Samples: Whole cell lysate (5, 15 and 50 µg) from HeLa cells. Antibodies: Affinity purified rabbit anti-GTPBP4 antibody (Product # A303-132A) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seconds.
Product Details
A303-132A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 200 and 250 of human GTP Binding Protein 4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chronic renal failure gene protein; FLJ10686; FLJ10690; FLJ39774; G protein-binding protein CRFG; GTP-binding protein 4; GTP-binding protein NGB; Nucleolar GTP-binding protein 1; unnamed protein product
Gene Aliases: CRFG; GTPBP4; NGB; NOG1
UniProt ID: (Human) Q9BZE4
Entrez Gene ID: (Human) 23560
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
osteoblast differentiation
negative regulation of DNA replication
negative regulation of cell proliferation
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of protein ubiquitination
ribosome biogenesis
ribosomal large subunit biogenesis
protein stabilization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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