Search

  • Contáctenos
  • Orden Rápida

Bethyl Laboratories

FOXC1 Polyclonal Antibody

View all (12) FOXC1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
FOXC1 Polyclonal Antibody

Product Details

A303-519A

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (IHC)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 275 and 325 of human Forkhead Box C1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: forkhead box C1 protein; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; HGNC:3800; myeloid factor-delta

View more View less

Gene Aliases: ARA; ASGD3; FKHL7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; RIEG3

View more View less

UniProt ID: (Human) Q12948

View more View less

Entrez Gene ID: (Human) 2296

View more View less

Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding DNA binding, bending sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development ossification angiogenesis ovarian follicle development blood vessel development eye development ureteric bud development in utero embryonic development somitogenesis kidney development lymph vessel development endochondral ossification blood vessel remodeling heart morphogenesis apoptotic process involved in outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway brain development heart development cell proliferation germ cell migration anatomical structure morphogenesis positive regulation of gene expression positive regulation of epithelial to mesenchymal transition mesenchymal cell development neural crest cell development cell migration negative regulation of angiogenesis cerebellum development cell differentiation collagen fibril organization glycosaminoglycan metabolic process lacrimal gland development embryonic heart tube development maintenance of lens transparency vascular endothelial growth factor signaling pathway odontogenesis of dentin-containing tooth camera-type eye development positive regulation of DNA binding positive regulation of keratinocyte differentiation positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation mesenchymal cell differentiation artery morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation chemokine-mediated signaling pathway cellular response to epidermal growth factor stimulus glomerular epithelium development regulation of blood vessel diameter negative regulation of lymphangiogenesis positive regulation of hematopoietic progenitor cell differentiation positive regulation of hematopoietic stem cell differentiation negative regulation of apoptotic process involved in outflow tract morphogenesis positive regulation of core promoter binding cellular response to chemokine
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support