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Bethyl Laboratories
VPS11 Polyclonal Antibody
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FIGURE: 1 / 1
VPS11 Antibody (A303-527A) in WB
Detection of human VPS11 by western blot and immunoprecipitation. Samples: Whole cell lysate from HEK293T (15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), Jurkat (J; 50 µg) and HeLa (H; 50 µg) cells. Antibodies: Affinity purified rabbit anti-VPS11 antibody (Product # A303-527A) used for WB at 0.1 µg/mL (A) and 1 µg/mL (B) and used for IP at 6 µg/mg lysate. VPS11 was also immunoprecipitated by rabbit anti-VPS11 antibody A303-528A, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) ... View More
Product Details
A303-527A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 550 and 600 of Human Vacuolar Protein Sorting 11.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVPS11; RING finger protein 108; unnamed protein product; vacuolar protein sorting 11 homolog; Vacuolar protein sorting-associated protein 11 homolog; VPS11, CORVET/HOPS core subunit
Gene Aliases: DYT32; END1; HLD12; HLD12; DYT32; hVPS11; PEP5; PP3476; RNF108; VPS11
UniProt ID: (Human) Q9H270
Entrez Gene ID: (Human) 55823
intracellular protein transport
vesicle docking involved in exocytosis
autophagy
endosome organization
vacuole organization
endosome to lysosome transport
protein transport
vesicle-mediated transport
protein ubiquitination
regulation of protein stability
negative regulation of intracellular estrogen receptor signaling pathway
endosomal vesicle fusion
regulation of SNARE complex assembly
positive regulation of protein catabolic process
organelle fusion
regulation of organelle assembly
positive regulation of protein targeting to mitochondrion
positive regulation of early endosome to late endosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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