The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Full Length, Active
Gene ID (Entrez)
PKCA, PKC-A, PRKACA
PKC Kinase Family
Contents & Storage
Storage Buffer: 50 mM Tris-HCl, pH 8.0, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.