Rapid transport of internalized P-selectin to late endosomes and the TGN: roles in regulating cell surface expression and recycling to secretory granules.
AuthorsStraley KS, Green SA
JournalJ Cell Biol
PubMed ID11018057
'Prior studies on receptor recycling through late endosomes and the TGN have suggested that such traffic may be largely limited to specialized proteins that reside in these organelles. We present evidence that efficient recycling along this pathway is functionally important for nonresident proteins. P-selectin, a transmembrane cell adhesion protein involved ... More
Quantitative analysis of sex-pheromone coding in the antennal lobe of the moth Agrotis ipsilon: a tool to study network plasticity.
AuthorsJarriault D, Gadenne C, Rospars JP, Anton S,
JournalJ Exp Biol
PubMed ID19329752
'To find a mating partner, moths rely on pheromone communication. Released in very low amounts, female sex pheromones are used by males to identify and localize females. Depending on the physiological state (i.e. age, reproductive state), the olfactory system of the males of the noctuid moth Agrotis ipsilon is ''switched ... More
Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels.
AuthorsDonnelly EF, Geng L, Wojcicki WE, Fleischer AC, Hallahan DE,
JournalRadiology
PubMed ID11274552
'To evaluate the ability of a quantified power Doppler ultrasonography (US) system to help quantitate differences in tumor vascularity after radiation therapy and administration of tumor necrosis factor (TNF). Murine glioblastoma tumors were grown in the thighs of two sets of 25 mice each. Each mouse was assigned to one ... More
Potentiation of Fas-mediated apoptosis of murine granulosa cells by interferon-gamma, tumor necrosis factor-alpha, and cycloheximide.
AuthorsQuirk SM, Porter DA, Huber SC, Cowan RG,
JournalEndocrinology
PubMed ID9832422
'The Fas antigen is a transmembrane receptor belonging to the tumor necrosis factor-alpha (TNF) receptor family that, when activated by Fas ligand or agonistic antibodies, induces death by apoptosis. Although the presence of Fas antigen in ovarian tissues has been demonstrated, little is known about whether Fas antigen is functional ... More
Responsiveness of mouse corpora luteal cells to Fas antigen (CD95)-mediated apoptosis.
AuthorsQuirk SM, Harman RM, Huber SC, Cowan RG,
JournalBiol Reprod
PubMed ID10859241
Regression of the corpus luteum (CL) occurs by apoptosis. The Fas antigen (Fas) is a cell surface receptor that induces apoptosis in sensitive cells when bound to Fas ligand or agonistic anti-Fas monoclonal antibodies (Fas mAb). A potential role for Fas to induce apoptosis in dispersed CL cell preparations was ... More
Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis.
AuthorsSogabe H, Nangaku M, Ishibashi Y, Wada T, Fujita T, Sun X, Miwa T, Madaio MP, Song WC
JournalJ Immunol
PubMed ID11509624
To prevent complement-mediated autologous tissue damage, host cells express a number of membrane-bound complement inhibitors. Decay-accelerating factor (DAF, CD55) is a GPI-linked membrane complement regulator that is widely expressed in mammalian tissues including the kidney. DAF inhibits the C3 convertase of both the classical and alternative pathways. Although DAF deficiency ... More