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Invitrogen
Synapsin 1 Polyclonal Antibody
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FIGURE: 1 / 24
Synapsin 1 Antibody (A-6442) in ICC/IF
Immunofluorescent analysis of PSD-95 (green) and MAP2 (red) on rat primary cortical neurons cultured for 28 days in the B-27 Plus Neuronal Culture System (Product # A3653401). At day 28 the cells were fixed with 4% paraformaldehyde for 15 min, permeabilized with 0.1% triton x-100 for 30min, and blocked with 1% BSA for 30 min at room temperature. Cells were stained with anti-Synapsin-1 antibody (Product # A-... View More
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.jpg?time=20240507?time=20240507 "Synapsin 1 Antibody (A-6442) in IHC")
Product Details
A-6442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified bovine brain Synapsin 1
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
10 µg
Purification
IgG fraction
Storage buffer
5mM Ammonium bicarbonate
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has little or no activity against Synapsin II.
Storage and reconstitution: when stored at -20°C or below, the lyophilized antibody should retain full activity for over one year. Reconstitute using 50 µL PBS, pH 7.4, to yield a 0.2 mg/mL solution. If storing at 0-4°C, add sodium azide to a final concentration of 2mM. For longer storage, divide the solution into aliquots and freeze at -20°C, avoiding freeze/thaw cycles.
Target Information
SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brain protein 4.1; synapsin 1; Synapsin I; synapsin Ib; Synapsin-1; truncated synapsin 1-S
Gene Aliases: EPILX; EPILX1; MRX50; Syn-1; SYN1; Syn1-S; SYN1a; SYN1b; SYNI
UniProt ID: (Human) P17600, (Bovine) P17599, (Rat) P09951, (Mouse) O88935
Entrez Gene ID: (Human) 6853, (Bovine) 281510, (Rat) 24949, (Mouse) 20964
chemical synaptic transmission
neurotransmitter secretion
regulation of neurotransmitter secretion
neuron development
modulation of synaptic transmission
synapse organization
synaptic vesicle clustering
regulation of synaptic vesicle cycle
synaptic vesicle cycle
regulation of synaptic vesicle exocytosis
metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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