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Invitrogen

NMDAR2A Polyclonal Antibody

16 Published Figures
25 References
View all (40) NMDAR2A antibodies

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NMDAR2A Polyclonal Antibody

Product Details

A-6473

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
View 18 publications 18 publications

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

1:500-1:5,000
-

Immunocytochemistry (ICC/IF)

-
View 3 publications 3 publications

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

3 µL
View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Fusion protein containing amino acid residues 1253-1391 of the C-terminal region of rat brain subunit 2A
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Amount

10 µg

Purification

IgG fraction

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536209

Product Specific Information

This antibody recognizes the 180 kDa 2A subunit from rat, mouse and human, and does not cross-react with the 2B or 2C subunits.

Storage and reconstitution: when stored at -20°C or below, the lyophilized antibody should retain full activity for over one year. Reconstitute using 50 µL PBS, pH 7.4, to yield a 0.2 mg/mL solution. If storing at 0-4°C, add sodium azide to a final concentration of 2mM. For longer storage, divide the solution into aliquots and freeze at -20°C, avoiding freeze/thaw cycles.

Target Information

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: GluN2A; GluRepsilon1; Glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA 2A; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531; unnamed protein product

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Gene Aliases: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A

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UniProt ID: (Human) Q12879, (Mouse) P35436, (Rat) Q00959

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Entrez Gene ID: (Human) 2903, (Mouse) 14811, (Rat) 24409

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity cation channel activity calcium channel activity protein binding zinc ion binding ligand-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity metal ion binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential receptor activity ionotropic glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity glutamate binding protein kinase binding voltage-gated cation channel activity protein complex binding glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity cell adhesion molecule binding ATPase binding scaffold protein binding transmembrane signal receptor
Process(es)
startle response response to amphetamine ion transport calcium ion transport glutamate receptor signaling pathway chemical synaptic transmission brain development learning or memory learning memory visual learning response to xenobiotic stimulus response to wounding sensory perception of pain calcium-mediated signaling neurogenesis protein catabolic process sleep directional locomotion ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic sodium ion transmembrane transport locomotion negative regulation of protein catabolic process regulation of membrane potential dopamine metabolic process serotonin metabolic process positive regulation of apoptotic process response to ethanol regulation of synaptic plasticity regulation of neuronal synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission protein localization to postsynaptic membrane regulation of cation transmembrane transport cellular response to beta-amyloid positive regulation of excitatory postsynaptic potential action potential transport cation transport locomotory behavior protein localization positive regulation of cell death regulation of ion transmembrane transport response to drug regulation of long-term neuronal synaptic plasticity rhythmic process detection of mechanical stimulus involved in sensory perception of pain protein tetramerization regulation of sensory perception of pain cellular response to amino acid stimulus cellular response to zinc ion response to light stimulus response to carbohydrate response to manganese ion response to organic cyclic compound response to amine spinal cord development hippocampus development cerebral cortex development response to cocaine response to calcium ion response to methylmercury response to other organism response to ammonium ion response to fungicide cellular response to magnesium ion cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid
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