Search

  • Contáctenos
  • Orden Rápida

Bethyl Laboratories

PDGFR alpha Recombinant Rabbit Monoclonal Antibody (BLR128H)

View all (88) PDGFRA (CD140a) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
PDGFR alpha Recombinant Rabbit Monoclonal Antibody (BLR128H)

Product Details

A700-128-T

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Immunoprecipitation (IP)

6 µL/mg of lysate
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR128H

Immunogen

Recombinant protein representing the extracellular domain of Human Platelet derived growth factor receptor alpha (residues 24-525).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

10 µg

Purification

purified

Storage buffer

BBS, pH 8.2

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunocytochemistry: Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Target Information

PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; CD140a antigen; MGC74795; OTTHUMP00000218656; PDGF A-chain; PDGF alpha chain; PDGF Receptor alpha; PDGF subunit A; PDGF-1; PDGF-R-alpha; PDGFR-2; pdgfr-a; PDGFR-alpha; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; unnamed protein product

View more View less

Gene Aliases: AI115593; CD140A; PDGFR-2; PDGFR2; PDGFRA; RHEPDGFRA

View more View less

UniProt ID: (Human) P16234, (Mouse) P26618

View more View less

Entrez Gene ID: (Human) 5156, (Mouse) 18595

View more View less

Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity platelet-derived growth factor alpha-receptor activity vascular endothelial growth factor-activated receptor activity platelet-derived growth factor receptor binding protein binding ATP binding kinase activity transferase activity vascular endothelial growth factor binding protein homodimerization activity macromolecular complex binding platelet-derived growth factor binding phospholipase C activator activity transferase activity, transferring phosphorus-containing groups protein complex binding phosphatidylinositol 3-kinase binding transmembrane signal receptor
Process(es)
luteinization in utero embryonic development cell activation hematopoietic progenitor cell differentiation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway estrogen metabolic process positive regulation of cell proliferation female gonad development anatomical structure morphogenesis organ morphogenesis negative regulation of platelet activation cell migration peptidyl-tyrosine phosphorylation signal transduction involved in regulation of gene expression extracellular matrix organization lung development adrenal gland development positive regulation of cell migration male genitalia development regulation of actin cytoskeleton organization Leydig cell differentiation cellular response to reactive oxygen species platelet-derived growth factor receptor-alpha signaling pathway positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway wound healing odontogenesis of dentin-containing tooth protein autophosphorylation platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis skeletal system morphogenesis positive regulation of calcium-mediated signaling white fat cell differentiation positive regulation of chemotaxis positive regulation of protein kinase B signaling cardiac myofibril assembly palate development face morphogenesis cell chemotaxis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to amino acid stimulus metanephric glomerular capillary formation regulation of mesenchymal stem cell differentiation protein phosphorylation positive regulation of cytosolic calcium ion concentration multicellular organism development positive regulation of phospholipase C activity phosphorylation cellular response to platelet-derived growth factor stimulus positive regulation of phosphatidylinositol 3-kinase activity positive regulation of DNA replication phosphatidylinositol-mediated signaling regulation of chemotaxis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support