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Bethyl Laboratories
Lasu1/Ureb1 Recombinant Rabbit Monoclonal Antibody (BLR129H)
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Product Details
A700-129CF
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR129H
Immunogen
Peptide representing a region between residue 2250 and 2300 of Human E3 ubiquitin-protein ligase HUWE1 (aka Lasu1, Ureb1).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
BBS, pH 8.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; DNA binding protein; E3 ubiquitin-protein ligase HUWE1; E3Histone; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; KIAA0312; large structure of URE B1; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase; Mcl-1 ubiquitin ligase E3; MULE; RP3-339A18.4; ubiquitin ligase with HECT domain; unnamed protein product; upstream regulatory element binding protein 1; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; UREB1
Gene Aliases: 5430439H10Rik; ARF-BP1; AU041296; C430014N20Rik; C80292; Gm1718; HECTH9; HSPC272; HUWE1; Ib772; KIAA0312; KIAA1578; LASU1; MRXST; MULE; URE-B1; UREB1
UniProt ID: (Human) Q7Z6Z7, (Mouse) Q7TMY8
Entrez Gene ID: (Human) 10075, (Mouse) 59026
DNA binding
RNA binding
ubiquitin-protein transferase activity
protein binding
transferase activity
ubiquitin-ubiquitin ligase activity
ubiquitin protein ligase activity
histone ubiquitin ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
poly(A) RNA binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein polyubiquitination
DNA repair
base-excision repair
chromatin remodeling
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
Golgi organization
I-kappaB kinase/NF-kappaB signaling
negative regulation of mitochondrial fusion
protein ubiquitination
cell differentiation
positive regulation of protein ubiquitination
circadian regulation of gene expression
peroxisome proliferator activated receptor signaling pathway
negative regulation of peroxisome proliferator activated receptor signaling pathway
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
rhythmic process
membrane fusion
protein K48-linked ubiquitination
protein branched polyubiquitination
positive regulation of protein targeting to mitochondrion
positive regulation of type 2 mitophagy
histone ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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