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Bethyl Laboratories
FOXC2 Recombinant Rabbit Monoclonal Antibody (BLR184J)
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Product Details
A700-184
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR184J
Immunogen
Peptide representing a region between residue 350 and 400 of Human Forkhead box protein C2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
250 µg/mL
Amount
25 µg
Purification
purified
Storage buffer
BBS, pH 8.2, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunocytochemistry: Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
Target Information
Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BF-3; Brain factor 3; forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; Transcription factor FKH-14
Gene Aliases: Fkh14; FKHL14; FOXC2; Hfhbf3; LD; MFH-1; MFH1
UniProt ID: (Human) Q99958, (Mouse) Q61850
Entrez Gene ID: (Human) 2303, (Mouse) 14234
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
ossification
blood vessel development
patterning of blood vessels
metanephros development
ureteric bud development
somitogenesis
kidney development
lymph vessel development
lymphangiogenesis
blood vessel remodeling
heart morphogenesis
apoptotic process involved in outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
mesoderm development
heart development
cell proliferation
insulin receptor signaling pathway
anatomical structure morphogenesis
response to hormone
positive regulation of endothelial cell migration
neural crest cell development
cell differentiation
collagen fibril organization
positive regulation of cell adhesion mediated by integrin
embryonic heart tube development
positive regulation of vascular wound healing
camera-type eye development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesoderm formation
paraxial mesodermal cell fate commitment
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
glomerular endothelium development
glomerular visceral epithelial cell differentiation
glomerular mesangial cell development
positive regulation of cell migration involved in sprouting angiogenesis
regulation of blood vessel diameter
negative regulation of cold-induced thermogenesis
negative regulation of apoptotic process involved in outflow tract morphogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
positive regulation of integrin activation
regulation of blood vessel size
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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