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Bethyl Laboratories

Galectin-9/Gal-9 Recombinant Rabbit Monoclonal Antibody (BLR193J)

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Galectin-9/Gal-9 Recombinant Rabbit Monoclonal Antibody (BLR193J)

Product Details

A700-193

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1 µL/10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR193J

Immunogen

Peptide representing a region between residue 305 and the C-terminus (residue 355) of Human Galectin-9.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Amount

50 µg

Purification

purified

Storage buffer

BBS, pH 8.2, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunocytochemistry: Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Target Information

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H and RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ecalectin; gal-9; Gal9; Galectin9; HOM HD 21; lectin, galactose binding, soluble 5; lectin, galactoside-binding, soluble, 9; tumor antigen HOM-HD-21; unnamed protein product; urate transporter/channel protein

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Gene Aliases: gal-9; galectin-9; HUAT; LGALS35; Lgals5; LGALS9A

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UniProt ID: (Human) O00182, (Mouse) O08573

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Entrez Gene ID: (Human) 3965, (Mouse) 16859

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Function(s)
protein binding galactose binding galactoside binding enzyme binding carbohydrate binding receptor agonist activity disaccharide binding oligosaccharide binding receptor binding protein serine/threonine kinase activator activity
Process(es)
natural killer cell tolerance induction negative regulation of T-helper 1 type immune response inflammatory response immune response female pregnancy positive regulation of gene expression negative regulation of gene expression response to lipopolysaccharide regulation of interleukin-4 production regulation of interleukin-5 production negative regulation of chemokine production negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway p38MAPK cascade positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of activated T cell proliferation positive regulation of viral entry into host cell NK T cell activation maternal process involved in female pregnancy positive regulation of activated T cell autonomous cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to interferon-gamma positive regulation of transforming growth factor beta production positive regulation of monocyte chemotactic protein-1 production mature conventional dendritic cell differentiation cellular response to virus regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of T cell migration positive regulation of dendritic cell chemotaxis negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of dendritic cell apoptotic process positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of dendritic cell differentiation positive regulation of cytokine production heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules transforming growth factor beta receptor signaling pathway regulation of T cell chemotaxis positive regulation of chemokine production positive regulation of interleukin-1 production negative regulation of natural killer cell activation regulation of natural killer cell differentiation regulation of T cell differentiation in thymus positive regulation of macrophage activation receptor clustering negative regulation of natural killer cell degranulation positive regulation of innate immune response maintenance of protein location positive regulation of regulatory T cell differentiation negative regulation of inflammatory response positive regulation of oxidoreductase activity positive regulation of SMAD protein import into nucleus positive regulation of defense response to bacterium regulation of T-helper 17 type immune response
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