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Bethyl Laboratories
FOX2/RBM9 Recombinant Rabbit Monoclonal Antibody (BLR215K)
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Product Details
A700-215
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR215K
Immunogen
Peptide representing a region between residue 1 and 50 of Human RNA binding protein fox-1 homolog 2 (aka RBM9, FOX2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
100 µg/mL
Amount
10 µg
Purification
purified
Storage buffer
BBS, pH 8.2, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fox-1 homolog B; fox-1 homolog Fxh; fox-1 homologue; Fyn-binding molecule 2; hexaribonucleotide-binding protein 2; RBFOX2; RBM9; RBM9; splice variant; RTA; repressor of tamoxifen transcriptional activity; repressor of tamoxifen transcriptional activity; RNA binding protein, fox-1 homolog 2; RNA-binding motif protein 9; RNA-binding protein; unnamed protein product
Gene Aliases: dJ106I20.3; Fbm2; Fox-2; FOX2; Fxh; HNRBP2; HRNBP2; RBM9; RTA
UniProt ID: (Human) O43251, (Mouse) Q8BP71
Entrez Gene ID: (Human) 23543, (Mouse) 93686
alternative mRNA splicing, via spliceosome
regulation of alternative mRNA splicing, via spliceosome
nervous system development
heart development
positive regulation of gene expression
regulation of definitive erythrocyte differentiation
radial glia guided migration of Purkinje cell
intracellular estrogen receptor signaling pathway
negative regulation of apoptotic process
regulation of RNA splicing
negative regulation of transcription, DNA-templated
positive regulation of vasoconstriction
dendrite morphogenesis
neuromuscular process controlling balance
negative regulation of mitochondrial depolarization
cardiac conduction
regulation of mitochondrial gene expression
cellular response to hydrogen peroxide
cellular response to retinoic acid
regulation of heart rate by cardiac conduction
mRNA alternative polyadenylation
negative regulation of membrane hyperpolarization
cellular response to angiotensin
cellular response to endothelin
RNA metabolic process
regulation of cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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