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Bethyl Laboratories
TCF1/TCF7 Recombinant Rabbit Monoclonal Antibody (BLR228K)
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Product Details
A700-228CF
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR228K
Immunogen
Peptide representing a region between residue 200 and 250 of Human Transcription factor 7 (TCF1/TCF7).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
BBS, pH 8.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HMG-box; OTTHUMP00000159390; OTTHUMP00000159391; T-cell specific; T-cell-factor-7; T-cell-specific transcription factor 1; transcription factor 7 (T-cell specific, HMG-box); unnamed protein product
Gene Aliases: TCF-1; Tcf1
UniProt ID: (Human) P36402, (Mouse) Q00417
Entrez Gene ID: (Human) 6932, (Mouse) 21414
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
immune system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
tissue development
Wnt signaling pathway
neural tube development
cell differentiation
embryonic genitalia morphogenesis
T cell receptor V(D)J recombination
regulation of cell proliferation
gamma-delta T cell differentiation
negative regulation of apoptotic process
regulation of gamma-delta T cell differentiation
alpha-beta T cell differentiation
embryonic digestive tract morphogenesis
embryonic hindgut morphogenesis
canonical Wnt signaling pathway
cellular response to interleukin-4
immune response
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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