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Bethyl Laboratories
ARID1A/BAF250 Recombinant Rabbit Monoclonal Antibody (BLR279L)
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Product Details
A700-279
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR279L
Immunogen
Peptide representing a region between residue 750 and 800 of Human AT-rich interactive domain-containing protein 1A.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
50 µg/mL
Amount
5 µg
Purification
purified
Storage buffer
BBS, pH 8.2, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARID domain-containing protein 1A; ARID family protein; AT rich interactive domain 1A (SWI-like); AT rich interactive domain 1A (Swi1 like); brain protein 120; BRG1-associated factor 250a; chromatin remodeling factor p250; h BM029; osa homolog 1; OSA1 nuclear protein; SNF/SWI complex largest subunit; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; unnamed protein product
Gene Aliases: 1110030E03Rik; B120; BAF250; BAF250a; BM029; C1orf4; CSS2; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
UniProt ID: (Human) O14497, (Mouse) A2BH40
Entrez Gene ID: (Human) 8289, (Mouse) 93760
negative regulation of transcription from RNA polymerase II promoter
formation of primary germ layer
neural tube closure
cardiac chamber development
optic cup formation involved in camera-type eye development
chromatin organization
nucleosome disassembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
gastrulation
embryo implantation
stem cell population maintenance
regulation of mitotic metaphase/anaphase transition
forebrain development
positive regulation of T cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
cardiac muscle cell differentiation
placenta blood vessel development
regulation of G0 to G1 transition
positive regulation of stem cell population maintenance
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
positive regulation of gene expression, epigenetic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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