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Bethyl Laboratories
SMARCA2/BRM Recombinant Rabbit Monoclonal Antibody (BLR301M)
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FIGURE: 1 / 3
SMARCA2/BRM Antibody (A700-301) in WB
Detection of human SMARCA2/BRM by western blot. Samples: Whole cell lysate (50 µg) from HeLa, KG-1, Daudi, THP-1, and MJ cells prepared using NETN lysis buffer. Antibody: Rabbit anti-SMARCA2/BRM recombinant monoclonal antibody [BLR301M] (A700-301 lot 1) used at 1:1,000. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). Detection: Chemiluminescence with an exposure time of 10 seconds. Lower Panel: Rabbit anti-Actin recombinant monoclonal antibody [BLR057F] (A700-057).
Product Details
A700-301
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR301M
Immunogen
Recombinant antibody was purified from cell culture supernatant. Immunogen was a peptide representing a region between residue 1325 and 1375 of human SMARCA2/BRM using the numbering given in entry NP_003061.3 (Gene ID 6595).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
250 µg/mL
Amount
25 µg
Purification
purified
Storage buffer
PBS, pH 6.8-7.4, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SMARCA2 encodes a protein that is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA2; BAF190B; brahma homolog; BRG1-associated factor 190B; FLJ36757; global transcription activator homologous sequence; hBRM; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; putative global transcription activator SNF2L2; SAMRCA2; SNF2-alpha; SNF2/SWI2-like protein 2; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; unnamed protein product
Gene Aliases: BAF190; BAF190B; BIS; BRM; hBRM; hSNF2a; NCBRS; SMARCA2; SNF2; SNF2A; SNF2L2; SNF2LA; Sth1p; SWI2
UniProt ID: (Human) P51531
Entrez Gene ID: (Human) 6595
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatid development
nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of mitotic metaphase/anaphase transition
negative regulation of cell growth
heterochromatin assembly
positive regulation of T cell differentiation
negative regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of G0 to G1 transition
positive regulation of stem cell population maintenance
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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