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Bethyl Laboratories
PALB2 Recombinant Rabbit Monoclonal Antibody (BLR339M)
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FIGURE: 1 / 2
PALB2 Antibody (A700-339) in WB
Detection of human PALB2 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, Jurkat, U-937, KG-1, and MJ cells prepared using NETN lysis buffer. Antibody: Rabbit anti-PALB2 recombinant monoclonal antibody [BLR339M] (A700-339) used at 1:1,000. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). Detection: Chemiluminescence with an exposure time of 30 seconds. Lower Panel: Rabbit anti-Actin recombinant monoclonal antibody [BLR057F] (A700-057).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
A700-339
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR339M
Immunogen
Recombinant antibody was purified from cell culture supernatant. Immunogen was a peptide representing a region between residue 350 and 400 of human Partner and localizer of BRCA2 (aka PALB2) using the numbering given in entry NP_078951.2 (Gene ID 79728).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 6.8-7.4
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ21816; mutant partner and localizer of BRCA2; unnamed protein product
Gene Aliases: BROVCA5; FANCN; PNCA3
UniProt ID: (Human) Q86YC2
Entrez Gene ID: (Human) 79728
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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