Search

  • Contact Us
  • Quick Order

Bethyl Laboratories

Neurofibromin 1 Recombinant Rabbit Monoclonal Antibody (BLR345M)

View all (21) NF1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Neurofibromin 1 Recombinant Rabbit Monoclonal Antibody (BLR345M)

Product Details

A700-345

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Flow Cytometry (Flow)

1 µL/1x10^6 cells
-

Immunoprecipitation (IP)

20 µL/mg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR345M

Immunogen

Recombinant antibody was purified from cell culture supernatant. Immunogen was a peptide representing a region between residue 2789 and the C-terminus (residue 2839) of human Neurofibromin 1 using the numbering given in entry NP_001035957.1 (Gene ID 4763).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

100 µg/mL

Amount

10 µg

Purification

purified

Storage buffer

PBS, pH 6.8-7.4, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp686J1293; FLJ21220; neurofibromatosis 1; neurofibromatosis-related protein NF-1; unnamed protein product

View more View less

Gene Aliases: Dsk9; E030030H24Rik; Mhdadsk9; Nf-1; NFNS; VRNF; WSS

View more View less

UniProt ID: (Human) P21359, (Mouse) Q04690

View more View less

Entrez Gene ID: (Human) 4763, (Mouse) 18015

View more View less

Function(s)
GTPase activator activity protein binding phosphatidylethanolamine binding phosphatidylcholine binding microtubule binding syndecan binding
Process(es)
MAPK cascade osteoblast differentiation metanephros development response to hypoxia liver development negative regulation of endothelial cell proliferation regulation of cell-matrix adhesion cell communication Ras protein signal transduction negative regulation of neuroblast proliferation brain development peripheral nervous system development heart development visual learning Schwann cell development spinal cord development forebrain astrocyte development cerebral cortex development myelination in peripheral nervous system actin cytoskeleton organization extracellular matrix organization collagen fibril organization adrenal gland development negative regulation of cell migration wound healing positive regulation of apoptotic process negative regulation of MAPK cascade pigmentation protein kinase B signaling positive regulation of neuron apoptotic process regulation of blood vessel endothelial cell migration positive regulation of GTPase activity regulation of bone resorption regulation of glial cell differentiation regulation of angiogenesis negative regulation of fibroblast proliferation sympathetic nervous system development camera-type eye morphogenesis negative regulation of oligodendrocyte differentiation smooth muscle tissue development artery morphogenesis forebrain morphogenesis regulation of developmental process cognition regulation of intracellular signal transduction positive regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion negative regulation of protein kinase activity skeletal muscle tissue development negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression positive regulation of neuron projection development Schwann cell differentiation negative regulation of angiogenesis amygdala development neural tube development regulation of synaptic transmission, GABAergic cellular response to heat negative regulation of Rac protein signal transduction regulation of cell proliferation negative regulation of protein import into nucleus negative regulation of MAP kinase activity regulation of MAPK cascade regulation of neuron differentiation negative regulation of osteoclast differentiation positive regulation of adenylate cyclase activity negative regulation of Ras protein signal transduction negative regulation of neurotransmitter secretion regulation of long-term neuronal synaptic plasticity negative regulation of astrocyte differentiation hair follicle maturation regulation of synapse organization long-term synaptic potentiation gamma-aminobutyric acid secretion, neurotransmission glutamate secretion, neurotransmission regulation of ERK1 and ERK2 cascade observational learning postsynaptic signal transduction regulation of modification of postsynaptic structure regulation of postsynapse organization regulation of long-term synaptic potentiation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support