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Bethyl Laboratories
GITR/TNFRSF18 Recombinant Rabbit Monoclonal Antibody (BLR068G)
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FIGURE: 1 / 6
GITR/TNFRSF18 Antibody (A700-068) in ICC/IF
Detection of human GITR/TNFRSF18 by immunocytochemistry. Sample: FFPE section of RPMI-8226 cells. Antibody: Rabbit anti-GITR/TNFRSF18 recombinant monoclonal antibody [BLR068G] (Product # A700-068) (lot 1) used at 1:125. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-501P). Substrate: DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
A700-068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR068G
Immunogen
Peptide representing a region between residue 191 and the C-terminus (residue 241) of human Tumor necrosis factor receptor superfamily member 18 (GITR).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
purified
Storage buffer
BBS, pH 7.8 to 8.6
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activation-inducible TNFR family receptor; AITR; GITR; TNF receptor homolog; similar to murine glucocorticoid-induced TNFR-related protein; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; UNQ319; variant (4) contains an extra coding segment, which leads to a frame shift, compared to variant 1 and 3; resulting protein (isoform 4) contains a transmembrane domain (identical to variant 1 and 3) and a longer cytoplasmic domain with a sequence different
Gene Aliases: AITR; CD357; ENERGEN; GITR; GITR-D
UniProt ID: (Human) Q9Y5U5
Entrez Gene ID: (Human) 8784
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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