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Invitrogen
Oligomer A11 Polyclonal Antibody
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FIGURE: 1 / 13
Oligomer A11 Antibody (AHB0052) in WB
Rabbit Anti-Oligomer (A11) Polyclonal Antibody. 1 µg of soluble Abeta42 monomers, Abeta42 oligomers, Ab42 fibrils, IAPP oligomers and alpha-Synuclein oligomers was applied to a nitrocellulose membrane and probed with Rabbit Anti-oligomer (A11) polyclonal antibody (top row; Product # AHB0052) or with 6E10 (bottom row, Product # 44-352). Anti-oligomer antibody recognizes all types of oligomers, but not monomers or fibrils. 6E10 recognizes all species of Abeta without regard to conformation, but not IAPP or alpha-Synuclein.
Product Details
AHB0052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Bacteria,
Cat,
Cynomolgus monkey,
Fruit fly,
Human,
Mouse,
Nematode,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic molecular mimic of soluble oligomers.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35.
Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.
Target Information
Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Antioligomer A11; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; Insulin-1; preproinsulin; proinsulin
Gene Aliases: IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins1; Ins2-rs1; IRDN; MODY10; PNDM4
UniProt ID: (Human) P01308, (Rat) P01322, (Mouse) P01325
Entrez Gene ID: (Human) 3630, (Rat) 24505, (Mouse) 16333
positive regulation of cytokine production
negative regulation of acute inflammatory response
glucose metabolic process
regulation of transcription, DNA-templated
acute-phase response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
positive regulation of nitric oxide mediated signal transduction
positive regulation of neuron projection development
positive regulation of cell growth
positive regulation of cell migration
regulation of protein localization
nitric oxide-cGMP-mediated signaling pathway
TORC1 signaling
wound healing
negative regulation of protein catabolic process
vasodilation
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cell differentiation
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of translation
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
positive regulation of lipid biosynthetic process
regulation of synaptic plasticity
regulation of protein secretion
negative regulation of protein secretion
positive regulation of protein secretion
cognition
negative regulation of lipid catabolic process
positive regulation of nitric-oxide synthase activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of peptide hormone secretion
positive regulation of brown fat cell differentiation
positive regulation of protein localization to nucleus
positive regulation of long-term synaptic potentiation
cellular response to oxygen-containing compound
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
neuron projection maintenance
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of feeding behavior
MAPK cascade
regulation of cellular amino acid metabolic process
response to organic substance
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
regulation of transmembrane transporter activity
activation of protein kinase B activity
positive regulation of cellular protein metabolic process
negative regulation of protein oligomerization
negative regulation of NAD(P)H oxidase activity
response to cytokine
response to peptide hormone
positive regulation of DNA replication
negative regulation of proteolysis
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
response to cAMP
carbohydrate metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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