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Alomone Labs, LTD
Leptin Receptor (extracellular) Polyclonal Antibody
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FIGURE: 1 / 7
Leptin Receptor (extracellular) Antibody (ALR-039-50UL) in IHC (F)
Expression of Leptin Receptor in mouse olfactory bulb. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Leptin Receptor (extracellular) Antibody (#ALR-039) (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. Leptin Receptor immunoreactivity (green) appears in the mitral layer (M). B. Pre-incubation of the antibody with Leptin Receptor (extracellular) Blocking Peptid... View More
Product Details
ALR-039-50UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide DNFNVLPDTKERFYAS, corresponding to amino acid residues 297-312 of mouse NPSR1. Extracellular, 3rd loop.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: DNFNVLPDTKERFYAS
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B219; CD antigen CD295; CD295; CD295 antigen; HuB219.2; LEP-R; Leptin receptor; Leptin receptor (fatty); leptin receptor gene-related protein; OB receptor; OB-R
Gene Aliases: Db; diabetes; Fa; Lepr; Leprb; LEPROT; Modb1; OB-RGRP; obese-like; obl; Obr
UniProt ID: (Rat) Q62959, (Mouse) P48356
Entrez Gene ID: (Rat) 24536, (Mouse) 16847
angiogenesis
ovulation from ovarian follicle
response to hypoxia
generation of precursor metabolites and energy
G-protein coupled receptor signaling pathway
female pregnancy
response to nutrient
cholesterol metabolic process
cytokine-mediated signaling pathway
leptin-mediated signaling pathway
response to nicotine
eating behavior
positive regulation of MAPK cascade
response to estrogen
response to leptin
negative regulation of gluconeogenesis
negative regulation of hydrolase activity
cellular response to organic substance
signal transduction
regulation of metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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