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Phospho-PKC zeta (Thr560) Polyclonal Antibody

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Phospho-PKC zeta (Thr560) Polyclonal Antibody

Product Details

BS-12690R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthesised phosphopeptide derived from human PKC zeta around the phosphorylation site of Thr560.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 14 - 3 - 3 - zeta isoform; atypical protein kinase C; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; protein kinase C zeta subspecies; Protein kinase C zeta type; unnamed protein product

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Gene Aliases: 14-3-3-zetaisoform; AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-ZETA; PKC2; Pkcz; PRKCZ; r14-3-3; R74924; zetaPKC

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UniProt ID: (Human) Q05513, (Rat) P09217, (Mouse) Q02956

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Entrez Gene ID: (Human) 5590, (Rat) 25522, (Mouse) 18762

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding zinc ion binding kinase activity transferase activity insulin receptor substrate binding metal ion binding protein serine kinase activity potassium channel regulator activity protein kinase binding protein domain specific binding phospholipase binding 14-3-3 protein binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
microtubule cytoskeleton organization protein phosphorylation inflammatory response signal transduction establishment of cell polarity negative regulation of protein complex assembly positive regulation of interleukin-10 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production cellular response to insulin stimulus intracellular signal transduction negative regulation of apoptotic process establishment or maintenance of epithelial cell apical/basal polarity positive regulation of T-helper 2 cell differentiation negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway positive regulation of NF-kappaB transcription factor activity long-term synaptic potentiation positive regulation of ERK1 and ERK2 cascade protein localization to plasma membrane neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production positive regulation of cell-matrix adhesion cell surface receptor signaling pathway long-term memory positive regulation of cell proliferation insulin receptor signaling pathway cell migration peptidyl-serine phosphorylation actin cytoskeleton reorganization activation of phospholipase D activity activation of protein kinase B activity cellular protein localization positive regulation of glucose import vesicle transport along microtubule negative regulation of peptidyl-tyrosine phosphorylation positive regulation of synaptic transmission positive regulation of protein transport protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization protein kinase C signaling positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion phosphorylation
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