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NCoR2 Polyclonal Antibody
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Product Details
BS-1420R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NCoR2, amino acids 2201-2525.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTG repeat protein 26; N-CoR2; nuclear receptor corepressor; Nuclear receptor corepressor 2; silencing mediator for retinoid and thyroid hormone receptors; Silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; silencing mediator of retinoid and thyroid hormone receptors extended isoform splice variant 1; transcriptional corepressor; SMAP270; SMRT; SMRTe; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TRAC
Gene Aliases: CTG26; N-CoR; N-CoR2; NCOR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1
UniProt ID: (Human) Q9Y618, (Mouse) Q9WU42
Entrez Gene ID: (Human) 9612, (Mouse) 20602, (Rat) 360801
DNA binding
chromatin binding
transcription corepressor activity
Notch binding
protein binding
enzyme activator activity
ligand-dependent nuclear receptor binding
glucocorticoid receptor binding
histone deacetylase binding
retinoic acid receptor binding
macromolecular complex binding
retinoid X receptor binding
RNA polymerase II regulatory region DNA binding
protein complex binding
sequence-specific DNA binding
protein N-terminus binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
lactation
regulation of cellular ketone metabolic process
cerebellum development
response to estradiol
estrous cycle
negative regulation of transcription, DNA-templated
negative regulation of androgen receptor signaling pathway
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
in utero embryonic development
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
telencephalon development
cell proliferation in forebrain
forebrain development
glucose homeostasis
negative regulation of fat cell differentiation
white fat cell differentiation
Type I pneumocyte differentiation
regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein deacetylation
response to organonitrogen compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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