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IRAK2 Polyclonal Antibody
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Product Details
BS-1427R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IRAK2, amino acids 21-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a novel IRAK/Pelle family member; interleukin-1 receptor-associated kinase 2c; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; MGC150550; mu-IRAK-2; unnamed protein product
Gene Aliases: 6330415L08Rik; AI649099; IRAK-2; IRAK2
UniProt ID: (Human) O43187, (Mouse) Q8CFA1, (Rat) Q4QQS0
Entrez Gene ID: (Human) 3656, (Mouse) 108960, (Rat) 362418
nucleotide binding
protein kinase activity
protein binding
ATP binding
signaling adaptor activity
protein homodimerization activity
protein heterodimerization activity
binding, bridging
protein serine/threonine kinase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
regulation of cytokine-mediated signaling pathway
toll-like receptor signaling pathway
protein phosphorylation
signal transduction
activation of NF-kappaB-inducing kinase activity
lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
intracellular signal transduction
regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
response to interleukin-1
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
I-kappaB kinase/NF-kappaB signaling
Toll signaling pathway
toll-like receptor 4 signaling pathway
NIK/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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