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IL-23R Polyclonal Antibody
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Product Details
BS-1460R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IL-23R, amino acids 401-550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hemopoietic cytokine receptor; IBD17; IL 23R; IL-23 receptor; IL-23R endodomain protein; IL-23R3-F3; IL-23R soluble receptor; IL-23R2-F1; IL-23R soluble receptor; IL-23R3-F1; IL-23R soluble receptor; IL-23R4; IL-23R truncated endodomain protein; IL-23R2-F2; interleukin 23 receptor; interleukin 23 receptor-like; Interleukin-23 receptor; type I cytokine receptor; IL-23R1
Gene Aliases: IL-23R; IL23R; PSORS7
UniProt ID: (Human) Q5VWK5, (Mouse) Q8K4B4
Entrez Gene ID: (Human) 149233, (Dog) 609732, (Rat) 689932, (Mouse) 209590
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
immune system process
positive regulation of T-helper 1 type immune response
inflammatory response
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
response to interferon-gamma
interleukin-23-mediated signaling pathway
prolactin signaling pathway
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
innate immune response
positive regulation of osteoclast differentiation
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
receptor signaling pathway via STAT
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
biological_process
leukocyte mediated immunity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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