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FOXJ1/HFH-4 Polyclonal Antibody

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FOXJ1/HFH-4 Polyclonal Antibody

Product Details

BS-1775R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human FOXJ1, amino acids 161-260.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity. FOXJ1 also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: fork head homologue 4; Forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4; HNF-3/forkhead homolog 4; MGC35202

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Gene Aliases: CILD43; FKHL-13; FKHL13; FOXJ1; HFH-4; HFH4

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UniProt ID: (Human) Q92949, (Mouse) Q61660, (Rat) Q63247

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Entrez Gene ID: (Human) 2302, (Mouse) 15223, (Rat) 116557

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter central tolerance induction negative regulation of germinal center formation positive regulation of central B cell tolerance induction negative regulation of humoral immune response mediated by circulating immunoglobulin regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response spermatogenesis determination of left/right symmetry pattern specification process brain development heart development protein localization cell projection organization actin cytoskeleton organization regulation of epithelial cell differentiation ciliary basal body organization negative regulation of interleukin-6 production negative regulation of T cell differentiation in thymus axoneme assembly establishment of apical/basal cell polarity metanephric part of ureteric bud development negative regulation of T cell proliferation motile cilium assembly positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation negative regulation of B cell activation leukocyte migration cilium morphogenesis lung epithelium development epithelium development left/right pattern formation glomerular parietal epithelial cell development negative regulation of NIK/NF-kappaB signaling positive regulation of lung ciliated cell differentiation transcription, DNA-templated transcription from RNA polymerase II promoter cell differentiation negative regulation of NF-kappaB transcription factor activity cilium assembly negative regulation of interleukin-6 biosynthetic process activation of GTPase activity response to organic cyclic compound response to estradiol cellular response to growth factor stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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