Search

  • Contáctenos
  • Orden Rápida

Bioss

Phospho-PKC delta (Thr505, Thr507) Polyclonal Antibody

View all (41) PKC delta antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-PKC delta (Thr505, Thr507) Polyclonal Antibody

Product Details

BS-3727R

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human PKC delta around the phosphorylation site of Thr505.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The PKC family of serine/threonine kinases, including PRKCD (PKC delta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 1-May; kinase nPKC-delta; KPCD; nPKC-delta; PKCdeltaVIII; Protein kinase C delta type; protein kinase C delta variant IX; protein kinase C delta VIII; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C[d]; Tyrosine-protein kinase PRKCD; unnamed protein product

View more View less

Gene Aliases: AI385711; ALPS3; CVID9; D14Ertd420e; MAY1; nPKC-delta; PKC[d]; PKCD; PKCdelta; PRKCD

View more View less

UniProt ID: (Human) Q05655, (Mouse) P28867, (Rat) P09215

View more View less

Entrez Gene ID: (Human) 5580, (Mouse) 18753, (Rat) 170538

View more View less

Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity zinc ion binding kinase activity transferase activity enzyme binding protein kinase binding protein tyrosine kinase activator activity insulin receptor substrate binding metal ion binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups TIR domain binding non-receptor serine/threonine protein kinase
Process(es)
protein phosphorylation apoptotic process cellular response to DNA damage stimulus signal transduction intrinsic apoptotic signaling pathway in response to oxidative stress immunoglobulin mediated immune response peptidyl-serine phosphorylation peptidyl-threonine phosphorylation termination of signal transduction negative regulation of actin filament polymerization positive regulation of endodeoxyribonuclease activity positive regulation of superoxide anion generation regulation of actin cytoskeleton organization negative regulation of glial cell apoptotic process cellular response to UV intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis B cell proliferation neutrophil activation positive regulation of protein import into nucleus defense response to bacterium negative regulation of apoptotic process negative regulation of MAPK cascade regulation of mRNA stability post-translational protein modification negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response protein stabilization positive regulation of DNA metabolic process negative regulation of filopodium assembly cell chemotaxis cellular response to hydrogen peroxide protein kinase C signaling cellular response to fatty acid cellular response to hydroperoxide negative regulation of platelet aggregation cellular senescence phospholipase C/protein kinase C signal transduction positive regulation of phospholipid scramblase activity cellular response to angiotensin regulation of ceramide biosynthetic process positive regulation of ceramide biosynthetic process positive regulation of glucosylceramide catabolic process positive regulation of sphingomyelin catabolic process positive regulation of apoptotic signaling pathway response to oxidative stress cell cycle aspartate transport phosphorylation interleukin-10 production interleukin-12 production collagen metabolic process cellular response to oxidative stress positive regulation of protein dephosphorylation regulation of phosphorylation positive regulation of apoptotic process positive regulation of MAP kinase activity negative regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of glucose import protein autophosphorylation negative regulation of peptidyl-tyrosine phosphorylation positive regulation of response to DNA damage stimulus response to hypoxia aging response to heat response to mechanical stimulus response to glucose response to organonitrogen compound response to organic cyclic compound cellular response to insulin stimulus cellular response to glucose starvation response to drug response to hydrogen peroxide positive regulation of catalytic activity response to amino acid response to ethanol
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support