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Phospho-Cdc6 (Ser54) Polyclonal Antibody
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Product Details
BS-5246R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Cdc6 around the phosphorylation site of Ser54 [PL (p-S)PR].
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC18(S.pombe); Cdc18-related protein; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog; HsCdc18; HsCDC6; p62(cdc6); unnamed protein product
Gene Aliases: CDC18L; CDC6; HsCDC18; HsCDC6; MGORS5
UniProt ID: (Human) Q99741, (Mouse) O89033
Entrez Gene ID: (Human) 990, (Mouse) 23834, (Rat) 360621
DNA replication checkpoint
regulation of cyclin-dependent protein serine/threonine kinase activity
DNA replication
DNA replication initiation
traversing start control point of mitotic cell cycle
negative regulation of DNA replication
negative regulation of cell proliferation
regulation of mitotic metaphase/anaphase transition
positive regulation of cytokinesis
mitotic DNA replication checkpoint
positive regulation of fibroblast proliferation
cell division
positive regulation of chromosome segregation
cellular response to vasopressin
cellular response to angiotensin
cell cycle
mitotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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