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Phospho-DAXX (Ser495) Polyclonal Antibody

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Phospho-DAXX (Ser495) Polyclonal Antibody

Product Details

BS-5291R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human DAXX around the phosphorylation site of Ser495.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CENP-C binding protein; DADB-159G18.9; DAXX; Death domain-associated protein 6; death domain-binding protein; HDaxx; death-associated protein 6; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246; SMIM40; unnamed protein product

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Gene Aliases: BING2; DAP6; DAXX; EAP1; SMIM40

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UniProt ID: (Human) Q9UER7

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Entrez Gene ID: (Human) 1616, (Rat) 140926

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Function(s)
p53 binding transcription coactivator activity transcription corepressor activity protein binding enzyme binding protein kinase binding protein kinase activator activity heat shock protein binding ubiquitin protein ligase binding histone binding protein homodimerization activity androgen receptor binding RNA polymerase II sequence-specific DNA binding transcription factor binding transcription regulator inhibitor activity molecular condensate scaffold activity transcription factor binding protein N-terminus binding
Process(es)
chromatin organization nucleosome assembly chromatin remodeling regulation of transcription, DNA-templated apoptotic process JNK cascade extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression negative regulation of gene expression androgen receptor signaling pathway regulation of protein ubiquitination cellular response to heat cellular response to unfolded protein neuron intrinsic apoptotic signaling pathway in response to oxidative stress regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated cellular response to cadmium ion cellular response to copper ion cellular response to diamide cellular response to sodium arsenite negative regulation of transcription from RNA polymerase II promoter mitotic cytokinesis positive regulation of protein phosphorylation transcription, DNA-templated response to metal ion negative regulation of myotube differentiation chromatin modification PML body organization positive regulation of histone phosphorylation positive regulation of apoptotic process positive regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter cellular response to tumor necrosis factor cellular response to anoxia apoptotic signaling pathway positive regulation of neuron death positive regulation of apoptotic signaling pathway
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