'In addition to its long-studied presence in the cytoplasm, actin is also found in the nuclei of eukaryotic cells. The function and form (monomer, filament, or noncanonical oligomer) of nuclear actin are hotly debated, and its localization and dynamics are largely unknown. To determine the distribution of nuclear actin in ... More
Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes.
While most transcription factors exit the chromatin during mitosis and the genome becomes silent, a subset of factors remains and
Visualizing coronavirus RNA synthesis in time by using click chemistry.
AuthorsHagemeijer MC, Vonk AM, Monastyrska I, Rottier PJ, de Haan CA,
JournalJ Virol
PubMed ID22438542
Coronaviruses induce in infected cells the formation of replicative structures, consisting of double-membrane vesicles (DMVs) and convoluted membranes, where viral RNA synthesis supposedly takes place and to which the nonstructural proteins (nsp's) localize. Double-stranded RNA (dsRNA), the presumed intermediate in RNA synthesis, is localized to the DMV interior. However, as ... More
Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH.
Authors
JournalCell
PubMed ID29887381
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.
Authors
JournalMol Cell
PubMed ID31202577
Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.
Authors
JournalMol Cell
PubMed ID30554942
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression.
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JournalNat Cell Biol
PubMed ID31792379
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Authors
JournalMol Cell
PubMed ID30554943
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair.
Authors
JournalNucleic Acids Res
PubMed ID31184714
ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions.
Authors
JournalAdv Sci (Weinh)
PubMed ID33101843
A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage.
Authors
JournalNucleic Acids Res
PubMed ID33469661
Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation.
Authors
JournalCell
PubMed ID28086092
A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.