Spontaneous calcium waves in the developing enteric nervous system.
AuthorsHao MM, Bergner AJ, Hirst CS, Stamp LA, Casagranda F, Bornstein JC, Boesmans W, Vanden Berghe P, Young HM
JournalDev Biol
PubMed ID28528728
The enteric nervous system (ENS) is an extensive network of neurons in the gut wall that arises from neural crest-derived cells. Like other populations of neural crest cells, it is known that enteric neural crest-derived cells (ENCCs) influence the behaviour of each other and therefore must communicate. However, little is ... More
Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development.
AuthorsHao MM, Capoccia E, Cirillo C, Boesmans W, Vanden Berghe P
JournalFront Cell Neurosci
PubMed ID28280459
S100B is expressed in various types of glial cells and is involved in regulating many aspects of their function. However, little is known about its role during nervous system development. In this study, we investigated the effect of inhibiting the onset of S100B synthesis in the development of the enteric ... More
The impact of detergents on the tissue decellularization process: A ToF-SIMS study.
AuthorsWhite LJ, Taylor AJ, Faulk DM, Keane TJ, Saldin LT, Reing JE, Swinehart IT, Turner NJ, Ratner BD, Badylak SF
JournalActa Biomater
PubMed ID27993639
Biologic scaffolds are derived from mammalian tissues, which must be decellularized to remove cellular antigens that would otherwise incite an adverse immune response. Although widely used clinically, the optimum balance between cell removal and the disruption of matrix architecture and surface ligand landscape remains a considerable challenge. Here we describe ... More
Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.
AuthorsLoganathan K, Salem Said E, Winterrowd E, Orebrand M, He L, Vanlandewijck M, Betsholtz C, Quaggin SE, Jeansson M
JournalPLoS One
PubMed ID29293543
Presence of tubulointerstitial fibrosis is predictive of progressive decline in kidney function, independent of its underlying cause. Injury to the renal microvasculature is a major factor in the progression of fibrosis and identification of factors that regulate endothelium in fibrosis is desirable as they might be candidate targets for treatment ... More
Dual roles of hydrogen peroxide in promoting zebrafish renal repair and regeneration.
AuthorsChen J, Yu T, He X, Fu Y, Dai L, Wang B, Wu Y, He J, Li Y, Zhang F, Zhao J, Liu C
JournalBiochem Biophys Res Commun
PubMed ID31248596
Acute renal injury (AKI) is a serious disorder of renal failure or renal damage that occurs within hours or days. At present, there is no approved pharmaceutical treatment for AKI. Zebrafish is an excellent model for studying the repair of AKI because of its remarkable ability to repair kidney injury. ... More
Neuronal Membrane Disruption Occurs Late Following Diffuse Brain Trauma in Rats and Involves a Subpopulation of NeuN Negative Cortical Neurons.
AuthorsHernandez ML, Chatlos T, Gorse KM, Lafrenaye AD
JournalFront Neurol
PubMed ID31824411
The repercussions of traumatic brain injury (TBI) endure years following the initial insult and involve chronic impairments/disabilities. Studies indicate that these morbidities stem from diffuse pathologies, however, knowledge regarding TBI-mediated diffuse pathologies, and in particular, diffuse neuronal membrane disruption, is limited. Membrane disruption has been shown to occur acutely following ... More
The hepatoprotective effects of Salvia plebeia R. Br. extract in zebrafish (Danio rerio).
AuthorsXiong G, Deng Y, Cao Z, Liao X, Zhang J, Lu H
JournalFish Shellfish Immunol
PubMed ID31654769
Salvia plebeia R. Br. is a traditional Chinese medicinal herb that has been widely used for the treatment of many inflammatory diseases such as hepatitis. However, the underlying molecular mechanism about the hepatoprotective effects of S. plebeia remains largely unknown. Here, we investigated the antioxidant activities and anti-inflammatory effects of ... More
Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum.
AuthorsTrentzsch M, Nyamugenda E, Miles TK, Griffin H, Russell S, Koss B, Cooney KA, Phelan KD, Tackett AJ, Iyer S, Boysen G, Baldini G
JournalCell Death Discov
PubMed ID32123584
Genetic obesity increases in liver phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio, inducing endoplasmic reticulum (ER) stress without concomitant increase of ER chaperones. Here, it is found that exposing mice to a palm oil-based high fat (HF) diet induced obesity, loss of liver PE, and loss of the ER chaperone Grp78/BiP in pericentral ... More