Engagement of the ATR-dependent DNA damage response at the human papillomavirus 18 replication centers during the initial amplification.
AuthorsReinson T, Toots M, Kadaja M, Pipitch R, Allik M, Ustav E, Ustav M,
JournalJ Virol
PubMed ID23135710
'We have previously demonstrated that the human papillomavirus (HPV) genome replicates effectively in U2OS cells after transfection using electroporation. The transient extrachromosomal replication, stable maintenance, and late amplification of the viral genome could be studied for high- and low-risk mucosal and cutaneous papillomaviruses. Recent findings indicate that the cellular DNA ... More
Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response.
Authors
JournalMol Cell
PubMed ID33022275
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
Authors
JournalCell
PubMed ID31002797
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
Authors
JournalNature
PubMed ID29795344
Human blastoids model blastocyst development and implantation.
Authors
JournalNature
PubMed ID34856602
Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal.
Authors
JournalNucleic Acids Res
PubMed ID32710616
CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.
Authors
JournalCancer Cell
PubMed ID31883968
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
Authors
JournalCancer Cell
PubMed ID33450198
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Authors
JournalCell
PubMed ID33159857
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Authors
JournalNature
PubMed ID31413369
Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline.
Authors
JournalCell
PubMed ID26522592
HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells.
Hypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heterogeneous environment is known to contribute to metastatic progression, little is known about the mechanism by which heterogeneic hypoxia contributes to ... More