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Invitrogen
CD14 Monoclonal Antibody (TüK4), Pacific Green™
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FIGURE: 1 / 1
CD14 Antibody (C11211) in Flow
Samples were acquired and analyzed using 405 nm excitation and 522/31 nm band pass emission filters on an Attune® Acoustic Focusing Cytometer (Life Technologies, Carlsbad, CA). The histogram shows cells stained with CD14 Mouse Anti-Human Pacific Green™ Conjugate (black line), and unstained lymphocytes (gray line).
Product Details
C11211
Product Specifications
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
TüK4
Immunogen
The CD14 antigen
Conjugate
Excitation/Emission Max
415/502 nm
View spectra
Form
Liquid
Storage conditions
4°C
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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