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OriGene
PIK3CG Monoclonal Antibody (OTI4B9), TrueMAB™
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Product Details
CF505256
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI4B9
Immunogen
Full length human recombinant protein of human PIK3CG produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 3-kinase; catalytic subunit; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; PI3-kinase subunit gamma; pi3kcg; ptdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG; unnamed protein product
Gene Aliases: IMD97; p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3; PIK3CG
UniProt ID: (Human) P48736
Entrez Gene ID: (Human) 5294
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
transferase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
identical protein binding
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein serine kinase activity
angiogenesis
positive regulation of cytokine production
adaptive immune response
immune system process
dendritic cell chemotaxis
positive regulation of acute inflammatory response
respiratory burst involved in defense response
sphingosine-1-phosphate signaling pathway
lipid metabolic process
endocytosis
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of endothelial cell migration
T cell chemotaxis
negative regulation of triglyceride catabolic process
cell migration
neutrophil chemotaxis
secretory granule localization
regulation of cell adhesion mediated by integrin
positive regulation of Rac protein signal transduction
natural killer cell chemotaxis
phosphatidylinositol-3-phosphate biosynthetic process
T cell proliferation
T cell activation
mast cell degranulation
positive regulation of MAP kinase activity
protein kinase B signaling
innate immune response
regulation of angiogenesis
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of protein kinase B signaling
negative regulation of cardiac muscle contraction
platelet aggregation
cellular response to cAMP
neutrophil extravasation
hepatocyte apoptotic process
regulation of calcium ion transmembrane transport
negative regulation of fibroblast apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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