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PIK3CD Monoclonal Antibody (OTI2H3), TrueMAB™

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PIK3CD Monoclonal Antibody (OTI2H3), TrueMAB™

Product Details

CF801891

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2H3

Immunogen

Human recombinant protein fragment corresponding to amino acids 286-610 of human PIK3CD produced in E.coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PI3K delta; PI3K-p110delta; pi3kcd; PI3Kdelta; PI3Kp110delta; PIK3Kdelta; PIK3Kdelta SV20; PIK3Kdelta SV8; PIK3Kdelta SV8/20; PtdIns-3-kinase subunit p110-delta; unnamed protein product

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Gene Aliases: APDS; IMD14; IMD14A; IMD14B; p110D; P110DELTA; PI3K; PIK3CD; ROCHIS

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UniProt ID: (Human) O00329

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Entrez Gene ID: (Human) 5293

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Function(s)
nucleotide binding protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity transferase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Process(es)
natural killer cell differentiation positive regulation of cytokine production positive regulation of endothelial cell proliferation adaptive immune response immune system process leukocyte mediated immunity mast cell chemotaxis respiratory burst involved in defense response protein phosphorylation lipid metabolic process chemotaxis inflammatory response immune response signal transduction cell surface receptor signaling pathway positive regulation of endothelial cell migration positive regulation of gene expression T cell chemotaxis cell migration regulation of anatomical structure morphogenesis natural killer cell activation cell differentiation B cell differentiation T cell differentiation positive regulation of cell migration neutrophil chemotaxis T cell costimulation positive regulation of neutrophil apoptotic process natural killer cell chemotaxis B cell chemotaxis phosphatidylinositol-3-phosphate biosynthetic process vascular endothelial growth factor signaling pathway T cell activation B cell activation mast cell degranulation protein kinase B signaling innate immune response positive regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling T cell receptor signaling pathway B cell receptor signaling pathway positive regulation of developmental process positive regulation of multicellular organismal process mast cell differentiation neutrophil extravasation positive regulation of epithelial tube formation regulation of multicellular organismal development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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