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OriGene
TNNI3 Monoclonal Antibody (OTI8G8), TrueMAB™
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Product Details
CF807946
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI8G8
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 1-210 of human TNNI3
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); MGC116817; sarcomeric protein; TNNI3; Tpn1; troponin I type 3 (cardiac); Troponin I, cardiac muscle; unnamed protein product
Gene Aliases: CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1; TNNI3
UniProt ID: (Human) P19429
Entrez Gene ID: (Human) 7137
vasculogenesis
regulation of systemic arterial blood pressure by ischemic conditions
skeletal muscle contraction
cellular calcium ion homeostasis
regulation of muscle contraction
regulation of smooth muscle contraction
striated muscle contraction
heart development
regulation of cardiac muscle contraction by calcium ion signaling
muscle filament sliding
negative regulation of ATPase activity
ventricular cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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