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OriGene
LHX2 Monoclonal Antibody (OTI1A2), TrueMAB™
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FIGURE: 1 / 1
LHX2 Antibody (CF810306) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LHX2 (RC210786, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LHX2. (1. Positive lysates LY401508 (100 µg) and LC401508 (20 µg) can be purchased separately from OriGene.
Product Details
CF810306
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1A2
Immunogen
Human recombinant protein fragment corresponding to amino acids 220-406 of human LHX2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein LH-2; LIM homeo box protein 2; LIM homeobox protein 2; LIM HOX gene 2; LIM/homeobox protein Lhx2; MGC138390; unnamed protein product
Gene Aliases: ap; apterous; hLhx2; Lh-2; LH2; LH2A; LHX2; Lim2
UniProt ID: (Human) P50458, (Mouse) Q9Z0S2
Entrez Gene ID: (Human) 9355, (Mouse) 16870, (Rat) 296706
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
protein binding
sequence-specific DNA binding
metal ion binding
transcription factor activity, RNA polymerase II transcription factor binding
zinc ion binding
helix-turn-helix transcription factor
homeodomain transcription factor
DNA-binding transcription factor
gene-specific transcriptional regulator
neural tube closure
hair follicle development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
axon guidance
brain development
mesoderm development
dorsal/ventral pattern formation
telencephalon development
olfactory bulb development
telencephalon regionalization
cerebral cortex development
neurogenesis
neuron differentiation
maintenance of epithelial cell apical/basal polarity
negative regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
axon extension
negative regulation of neurogenesis
retina development in camera-type eye
positive regulation of neural precursor cell proliferation
transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of transcription regulatory region DNA binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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