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Proteintech
Occludin Recombinant Rabbit Monoclonal Antibody (8B2), CoraLite® Plus 488
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Product Details
CL488-80545
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8B2
Immunogen
Occludin fusion protein Ag26173
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VDDFRQPRY SSGGNFETPS KRAPAKGRAG RSKRTEQDHY ETDYTTGGES CDELEEDWIR EYPPITSDQQ RQLYKRNFDT GLQEYKSLQS ELDEINKELS RLDKELDDYR EESEEYMAAA DEYNRLKQVK GSADYKSKKN HCKQLKSKLS HIKKMVGDYD RQKT
Target Information
Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Occludin; phosphatase 1, regulatory subunit 115; tight junction protein; unnamed protein product
Gene Aliases: AI503564; BLCPMG; Ocl; OCLN; PPP1R115; PTORCH1
UniProt ID: (Human) Q16625, (Mouse) Q61146
Entrez Gene ID: (Pig) 397236, (Human) 100506658, (Mouse) 18260
positive regulation of lamellipodium assembly
positive regulation of gene expression
negative regulation of gene expression
epithelial cell migration
regulation of glucose transport
positive regulation of microtubule polymerization
maintenance of blood-brain barrier
cell-cell junction organization
positive regulation of glucose import
protein-containing complex assembly
bicellular tight junction assembly
positive regulation of wound healing
tight junction organization
protein localization to cell leading edge
positive regulation of maintenance of permeability of blood-brain barrier
methylation
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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