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Dopamine Receptor D1 Polyclonal Antibody, FITC

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Dopamine Receptor D1 Polyclonal Antibody, FITC

Product Details

D1RH-112-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Non-human primate, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 290-340 on human D-1 dopamine receptor protein.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(1A) dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor; DRD1; G-protein coupled receptor; unnamed protein product

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Gene Aliases: D1R; DADR; DRD1; DRD1A

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UniProt ID: (Human) P21728, (Pig) P50130

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Entrez Gene ID: (Human) 1812, (Pig) 100144487

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gs G-protein alpha-subunit binding G-protein coupled receptor activity dopamine neurotransmitter receptor activity protein binding heterotrimeric G-protein binding dopamine binding arrestin family protein binding G-protein coupled receptor
Process(es)
temperature homeostasis conditioned taste aversion behavioral fear response neuron migration synaptic transmission, dopaminergic response to amphetamine protein import into nucleus muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway dopamine receptor signaling pathway synapse assembly learning memory mating behavior grooming behavior locomotory behavior adult walking behavior feeding behavior associative learning visual learning response to xenobiotic stimulus astrocyte development dopamine transport cell migration transmission of nerve impulse neuronal action potential dentate gyrus development striatum development hippocampus development cerebral cortex GABAergic interneuron migration positive regulation of cell migration peristalsis operant conditioning synaptic transmission, glutamatergic regulation of dopamine metabolic process response to cocaine vasodilation dopamine metabolic process maternal behavior positive regulation of potassium ion transport positive regulation of MAPK cascade glucose import habituation sensitization behavioral response to cocaine positive regulation of release of sequestered calcium ion into cytosol regulation of dopamine uptake involved in synaptic transmission positive regulation of synaptic transmission, glutamatergic prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway long-term synaptic potentiation long term synaptic depression cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway modification of postsynaptic structure presynaptic modulation of chemical synaptic transmission positive regulation of neuron migration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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