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DNA PKcs Polyclonal Antibody

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DNA PKcs Polyclonal Antibody

Product Details

DNPK1-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 4000-4128 of human DNPK1 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA-activated protein kinase catalytic subunit; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNPK1; doxorubicin nephropathy; hyper-radiosensitivity of murine scid mutation, complementing 1; p460; protein kinase, DNA-activated, catalytic polypeptide; S473K; Ser-473 kinase; severe combined immunodeficiency; unnamed protein product

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Gene Aliases: AI326420; AU019811; DNA-PKC; DNA-PKcs; DNAPDcs; DNAPK; DNAPKc; DNPK1; DOXNPH; dxnph; HYRC; HYRC1; IMD26; p350; p460; PRKDC; S473K; scid; slip; XRCC7

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UniProt ID: (Human) P78527, (Mouse) P97313

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Entrez Gene ID: (Human) 5591, (Mouse) 19090, (Rat) 360748

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Function(s)
nucleotide binding DNA binding double-stranded DNA binding RNA binding protein kinase activity protein serine/threonine kinase activity DNA-dependent protein kinase activity protein binding ATP binding kinase activity transferase activity enzyme binding protein domain specific binding U3 snoRNA binding histone H2AXS139 kinase activity RNA polymerase II sequence-specific DNA binding transcription factor binding protein serine kinase activity transcription factor binding transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor poly(A) RNA binding molecular_function non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
maturation of 5.8S rRNA telomere maintenance double-strand break repair via homologous recombination somitogenesis negative regulation of protein phosphorylation activation of innate immune response B cell lineage commitment immature B cell differentiation pro-B cell differentiation T cell lineage commitment immune system process DNA repair double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination protein phosphorylation cellular response to DNA damage stimulus brain development heart development intrinsic apoptotic signaling pathway in response to DNA damage response to ionizing radiation response to gamma radiation telomere capping peptidyl-serine phosphorylation peptidyl-threonine phosphorylation lymphocyte differentiation replication fork processing mitotic G1 DNA damage checkpoint protein destabilization cellular response to insulin stimulus T cell differentiation in thymus V(D)J recombination immunoglobulin V(D)J recombination T cell receptor V(D)J recombination small-subunit processome assembly ectopic germ cell programmed cell death protein modification process ribosome biogenesis regulation of circadian rhythm positive regulation of apoptotic process negative regulation of apoptotic process innate immune response positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation positive regulation of translation positive regulation of transcription from RNA polymerase II promoter rhythmic process regulation of smooth muscle cell proliferation regulation of epithelial cell proliferation protein localization to chromatin regulation of cellular response to stress double-strand break repair via alternative nonhomologous end joining DNA repair-dependent chromatin remodeling cGAS/STING signaling pathway negative regulation of cGAS/STING signaling pathway regulation of hematopoietic stem cell differentiation positive regulation of platelet formation positive regulation of double-strand break repair via nonhomologous end joining immunoglobulin production negative regulation of immunoglobulin production positive regulation of immune system process phosphorylation positive regulation of fibroblast proliferation spleen development thymus development positive regulation of developmental growth signal transduction involved in mitotic G1 DNA damage checkpoint negative regulation of cellular senescence negative regulation of response to gamma radiation response to activity
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