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CPS1 Monoclonal Antibody (4A10)
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Product Details
H00001373-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, lambda
Class
Monoclonal
Type
Antibody
Clone
4A10
Immunogen
CPS1 (NP_001866, 1400 a.a. approximately 1500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: ANNVPATPVA WPSQEGQNPS LSSIRKLIRD GSIDLVINLP NNNTKFVHDN YVIRRTAVDS GIPLLTNFQV TKLFAEAVQK SRKVDSKSLF HYRQYSAGKA A
Target Information
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carbamoyl-phosphate synthase (ammonia); carbamoyl-phosphate synthase 1, mitochondrial; Carbamoyl-phosphate synthase [ammonia], mitochondrial; Carbamoyl-phosphate synthetase I; carbamoylphosphate synthetase I; CPSase I; CPSI; unnamed protein product
Gene Aliases: CPS1; CPSASE1; GATD6; PHN
UniProt ID: (Human) P31327
Entrez Gene ID: (Human) 1373
nucleotide binding
catalytic activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
endopeptidase activity
calcium ion binding
protein binding
ATP binding
phospholipid binding
glutamate binding
ligase activity
potassium ion binding
small molecule binding
macromolecular complex binding
metal ion binding
modified amino acid binding
urea cycle
liver development
'de novo' pyrimidine nucleobase biosynthetic process
glutamine metabolic process
midgut development
response to xenobiotic stimulus
response to toxic substance
response to zinc ion
response to amine
citrulline biosynthetic process
triglyceride catabolic process
response to food
response to lipopolysaccharide
response to glucagon
response to oleic acid
vasodilation
response to starvation
response to amino acid
cellular response to fibroblast growth factor stimulus
nitric oxide metabolic process
response to steroid hormone
homocysteine metabolic process
response to glucocorticoid
response to cAMP
anion homeostasis
response to growth hormone
hepatocyte differentiation
carbamoyl phosphate biosynthetic process
cellular response to ammonium ion
cellular response to cAMP
cellular response to glucagon stimulus
cellular response to oleic acid
response to dexamethasone
response to alcohol
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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